膠原蛋白多種型號抗體，*
膠原質(zhì)又稱膠原蛋白（Collagen），是細(xì)胞外基質(zhì)重要的組成成份，是組成各種細(xì)胞外間質(zhì)的聚合物在動物細(xì)胞中扮演結(jié)合組織的角色，同時(shí)也是動物結(jié)構(gòu)組織主要的構(gòu)造性蛋白質(zhì)，主要是以以下不溶性纖維蛋白的形式存在。
膠原蛋白是人體組織的主要成份，它與人體各器官組織及細(xì)胞有著不可分隔的關(guān)系，所以應(yīng)用于人體器官組織的修補(bǔ)及再生。膠原蛋白的相關(guān)醫(yī)學(xué)應(yīng)用包括膠原蛋白海綿，絲腺，薄膜（外科止血，用于心臟血管，神經(jīng)，口腔，骨科，皮膚，婦產(chǎn)手術(shù)等）傷口敷料，人工皮膚，血管，心瓣膜，眼角膜保護(hù)材料，注射式膠原蛋白（用于除皺，軟組織豐滿填補(bǔ)，治療尿失禁，尿液回流，骨科組織再生填料），藥物輔助機(jī)制，膠原蛋白基質(zhì)模板等用途。一般而言，蛋白質(zhì)的基本單位為氨基酸，而其膠原蛋白卻是維持緊實(shí)和彈性的主要成份之一。
產(chǎn)品名稱：I型膠原蛋白抗體
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Sheep,
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量130kDa
細(xì)胞定位細(xì)胞外基質(zhì) 分泌型蛋白
性 狀Liquid
濃 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Collagen I:1051-1150/1464
亞 型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹Collagens are highly conserved throughout evolution and are characterised by an uninterrupted "Glycine X Y" triplet repeat that is a necessary part of the triple helical structure. Type I collagen (95 kDa) is found in bone, cornea, skin and tendon. Mutations in the encoding gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for Platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor.
Function:
Type I collagen is a member of group I collagen (fibrillar forming collagen).
Subunit:
Trimers of one alpha 2(I) and two alpha 1(I) chains. Interacts with MRC2. Interacts with TRAM2. Subcellular Location : Secreted, extracellular space, extracellular matrix.
膠原蛋白多種型號抗體，*
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